1-(2-Methoxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester → tert-Butyl 3-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenethoxy)propanoate

Participants

Reaction Steps

The subtitled compound (834 mg) was prepared from tert-butyl 3-(3-bromophenethoxy)propanoate [Preparation 3, Step i)] and 1-(2-methoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole using a similar method to that described in Example 18, Step i). MS M+H-C4H8]+=319 (MultiMode+) 1H NMR (300 MHz, CDCl3) δ 7.78 (s, 1H), 7.72 (s, 1H), 7.37-7.22 (m, 3H), 7.07 (d, J=7.5 Hz, 1H), 4.32 (t, J=5.2 Hz, 2H), 3.78 (t, J=5.3 Hz, 2H), 3.70 (t, J=6.5 Hz, 2H), 3.68 (t, J=7.5 Hz, 2H), 3.35 (s, 3H), 2.89 (t, J=7.2 Hz, 2H), 2.49 (t, J=6.4 Hz, 2H), 1.47 (s, 9H)

Provenance & Evidence