N-(2,2-dimethoxyethyl)cyclohexanamine → HCID 59290406, compound

Participants

Reaction Steps

The subtitled compound (267 mg) was prepared from 3-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenethoxy)propanoic acid [Example 36 Step ii)] and N-(2,2-dimethoxyethyl)cyclohexanamine using a similar method to that described in Example 18, Step iii). MS [M+H-MeOH]+=456 (MultiMode+) 1H NMR (400 MHz, CD3OD) δ 7.95 (s, 1H), 7.81 and 7.80 (2×s, 1H), 7.40-7.37 (m, 1H), 7.35 (d, J=7.7 Hz, 1H), 7.23 and 7.22 (2×t, J=7.7 Hz, 1H), 7.05 (d, J=7.9 Hz, 1H), 4.52 and 4.36 (2×t, J=5.3 Hz, 1H), 4.30 (t, J=5.2 Hz, 2H), 4.04-3.95 and 3.69-3.60 (2×m, 1H), 3.77-3.63 (m, 6H), 3.34 (s, 3H), 3.32 (s, 3H), 3.31 (s, 3H), 3.34 and 3.25 (2×d, J=5.1 Hz, 2H), 2.87-2.81 (m, 2H), 2.67-2.60 (m, 2H), 1.93-0.99 (m, 10H); a ˜1:1 mixture of rotamers is observed.

Provenance & Evidence