HCID 59650731, compound → HCID 59650726, compound

HRID 909999Notes

Reaction equation

HRID 909999 reaction equation
C([O:8][C:9](=[O:24])[CH2:10][N:11]([CH2:13][CH2:14][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH3:16])[CH3:12])C1C=CC=CC=1>CO.[C].[Pd]>[C:20]([O:19][C:17]([N:15]([CH3:16])[CH2:14][CH2:13][N:11]([CH2:10][C:9]([OH:24])=[O:8])[CH3:12])=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

4

Reactant 1

HCID 59650731HCID 59650731, compound

Product 1

HCID 59650726HCID 59650726, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

534.3 mg (1.59 mmol) of {[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-amino}-acetic acid benzyl ester prepared in Process 1-A was dissolved in methanol (20 mL), and then 51 mg of 5% palladium-carbon was added, and this was stirred for 1 hour under hydrogen atmosphere at room temperature. Insoluble substances were removed by filtration, and the filtrate was concentrated to give 391.1 mg (100%) of {[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-amino}-acetic acid as a colorless viscous oil.

Workup

  1. customInsoluble substances were removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-68f42a0fd49a47fa88d71e8abe22ed89
Source dataset
uspto-grants-2011_09
Patent number
US08022047B2

Reaction notes

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