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HRID910005

反应详情

EQUATION

反应方程式

HRID 910005 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C
HCID10884505

未命名化合物

结构：C=C(C)CCCBr
HCID11789538

未命名化合物

结构：[I-].[I-].[Sm+2]
HCID178506586

未命名化合物

PRODUCTS

生成物

1
结构：C=C(C)CCC[C@](C)(O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@@]21C
HCID66899745

未命名化合物

收率 71%

PROCEDURE

实验过程

The coupling reaction of the protected pregnenolone 1 (500.0 mg, 1.16 mmol) with 5-bromo-2-methyl-1-pentene 9 (199.0 mg, 1.22 mmol) in the presence of samarium diiodide was performed under similar condition as described for the preparation of 2 to afford the 20S-hydroxy steroid 10 (419.0 mg, 0.82 mmol, 71%) as a white powder.

WORKUP

后处理

  1. customas described for the preparation of 2