Ethyl bromoacetate → HCID 44724849, compound

Participants

Reaction Steps

Prepared from 4-fluoro-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenol (282 mg) and ethyl bromoacetate according to GP2 to give 335 mg (91%) yellow solid: LC/MS (an10n8): Rt 3.16, m/z 339.0 [M−H]−; 1H NMR (CDCl3): δ 1.26 (t, J=7.0 Hz, 3H), 4.23 (t, J=7.1 Hz, 2H), 4.63 (s, 2H), 6.81 (dd, J=9.0, 4.0 Hz, 1H), 7.13 (ddd, J=8.9, 4.5, 3.0 Hz, 1H), 7.21 (dd, J=8.1, 3.2 Hz, 1H), 7.31-7.37 (m, 1H), 7.24-7.50 (m, 2H), 7.72-7.78 (m, 2H), 8.18 (s, 1H), 8.58 (s, 1H); 13C NMR (CDCl3): δ14.3, 61.8, 66.1, 114.0 (d, JCF=7.6 Hz), 116.8 (d, JCF=24.5 Hz), 118.3 (d, JCF=23.5 Hz), 119.7, 125.2, 127.7, 129.7, 131.8, 139.6, 142.8, 151.1 (d, JCF=2.2 Hz), 157.6 (d, JCF=241.1 Hz), 168.7, 187.1.

Provenance & Evidence