Ethyl bromoacetate → HCID 67240669, compound

HRID 910028Notes

Reaction equation

[Cl:1][C:2]1[C:3]([CH3:22])=[C:4]([C:9]([C:11]2[CH:12]=[N:13][N:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)=[O:10])[C:5]([OH:8])=[CH:6][CH:7]=1.Br[CH2:24][C:25]([O:27]CC)=[O:26]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:24][C:25]([OH:27])=[O:26])=[C:4]([C:9]([C:11]2[CH:12]=[N:13][N:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:15]=2)=[O:10])[C:3]=1[CH3:22]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 67240667HCID 67240667, compound

Product 1

HCID 67240669HCID 67240669, compound

Procedure

Prepared from (3-chloro-6-hydroxy-2-methyl-phenyl)-(1-phenyl-1H-pyrazol-4-yl)methanone and ethyl bromoacetate according to GP2 and GP3: LC/MS (an10p8): Rt 3.34 min, m/z 370.6 [M+1]+; 1H NMR (CDCl3): δ 2.44 (s, 3H), 4.77 (s, 2H), 6.92 (s, 1H), 7.39 (d, J=9.0 Hz, 1H), 7.46-7.51 (m, 2H), 7.59 (s, 1H), 7.72 (d, J=9.0 Hz, 2H), 8.19 (s, 1H), 8.52 (s, 1H), 10.39 (br s, 1H)

Sources & evidence

ORD record: ord-43c6a093c8344efcb63ddebabd9fcb0b
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08022063B2

Reaction notes

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