Ethyl bromoacetate → HCID 57658826, compound

HRID 910029Notes

Reaction equation

[Cl:1][C:2]1[C:3]([OH:22])=[C:4]([C:9]([C:11]2[CH:12]=[N:13][N:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.Br[CH2:24][C:25]([O:27]CC)=[O:26]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([C:9]([C:11]2[CH:12]=[N:13][N:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)=[O:10])[C:3]=1[O:22][CH2:24][C:25]([OH:27])=[O:26]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 688696AG-G-61747

Product 1

HCID 57658826HCID 57658826, compound

Procedure

Prepared from (3,5-dichloro-2-hydroxyphenyl)-(1-phenyl-1H-pyrazol-4-yl)methanone and ethyl bromoacetate according to GP2 and GP3: LC/MS (an10p8): Rt 3.27 min, m/z 390.5 [M+1]+; 1H NMR (CDCl3): δ 4.72 (s, 2H), 7.38-7.51 (m, 4H), 7.57-7.58 (m, 1H), 7.70 (d, J=8.1 Hz, 2H), 8.06 (s, 1H), 8.36 (s, 1H), 9.23 (br s, 1H).

Sources & evidence

ORD record: ord-09d1a20e00534343b212cf7344c22b3a
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08022063B2

Reaction notes

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