Ethyl 2-bromopropionate → HCID 11589717, compound

HRID 910030Notes

Reaction equation

HRID 910030 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]([C:8]([C:10]2[CH:11]=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)=[O:9])[CH:7]=1.Br[CH:23]([CH3:29])[C:24]([O:26]CC)=[O:25]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH:23]([CH3:29])[C:24]([OH:26])=[O:25])=[C:6]([C:8]([C:10]2[CH:11]=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)=[O:9])[CH:7]=1

Participants

3

Reactant 2

HCID 79040Ethyl 2-bromopropionateHCID 688693(5-Bromo-2-hydroxyphenyl)(1-phenyl-1H-pyrazol-4-yl)methanone

Product 1

HCID 11589717HCID 11589717, compound

Procedure

Prepared from (5-bromo-2-hydroxyphenyl)-(1-phenyl-1H-pyrazol-4-yl)ketone and ethyl 2-bromopropionate according to GP2 and GP3: LC/MS (an 10p8) Rt 2.51 min, m/z 415 [M+H]+; 1H NMR (CDCl3): δ 1.65 (d, J=6.8 Hz, 3H), 4.93 (q, J=6.8 Hz, 1H), 6.96 (d, J=8.9 Hz, 1H), 7.35-7.43 (m, 1H), 7.46-7.53 (m, 2H), 7.62 (dd, J=8.9, 2.5 Hz, 1H), 7.70-7.76 (m, 3H), 8.17 (s, 1H), 8.52 (s, 1H); 13C NMR (CDCl3): δ18.8, 75.2, 114.8, 116.7, 120.1, 124.4, 128.3, 130.0, 133.3, 136.2, 139.2, 143.3, 155.0, 173.1, 187.8.

Sources & evidence

ORD record
ord-cf2b9a127e254874ae6fd324948e020d
Source dataset
uspto-grants-2011_09
Patent number
US08022063B2

Reaction notes

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