HCID 58497067, compound → HCID 57658727, compound

Participants

Reaction Steps

To a solution of [4-bromo-2-(1-hydroxy-3-trimethylsilanylprop-2-ynyl)phenoxy]acetic acid ethyl ester (0.95 g, 2.46 mmol) in CH2Cl2 (10 mL) was added activated MnO2 in 2 portions (1.5 g+1 g), and the reaction was stirred for 90 min. The solid was filtered off through a celite pad and the filtrate was concentrated in vacuo to give the title compound as yellow oil (0.83 g, 2.16 mmol, 87%). LC/MS (an 10p8) Rt 4.70 min, m/z 383 [M+H]+; 1H NMR (CDCl3): δ 0.30 (s, 9H), 1.30 (t, 3H), 4.27 (q, 2H), 4.72 (s, 2H), 6.81 (d, 1H), 7.58 (dd, 1H), 8.10 (s, 1H).

Provenance & Evidence