Phosphorus oxychloride → HCID 16718582, compound

Participants

Reaction Conditions

Reaction Steps

0.40 g of 5-(4-chlorophenyl)-4-(2,5-dimethyl-4-thiazolyl)-6-methyl-2H-pyridazin-3-one and 2 ml of phosphorus oxychloride were mixed. The mixture was stirred for 1 hour on an oil bath of 110° C. The reaction mixture was allowed to cool to room temperature, then, concentrated under reduced pressure. To the resultant residue was added ethyl acetate and ice water. The mixture was stirred for about 5 minutes at room temperature, then, liquid-partitioned. The organic layer was washed with brine three times, and dried over anhydrous magnesium sulfate, then, concentrated under reduced pressure to obtain 0.40 g 3-chloro-5-(4-chlorophenyl)-4-(2,5-dimethyl-4-thiazolyl)-6-m ethylpyridazine (hereinafter, described as compound (1) of the present invention.).

Provenance & Evidence