Dimethylformamide → HCID 67414697, compound

Participants

Reaction Steps

87 mg of sodium hydride (55% oil dispersion) was added to 5 ml of DMF, and to this was added 0.27 g of 3-trifluoromethylpyrazole, and the mixture was stirred for 5 hours at room temperature. To the resultant mixture was added 0.25 g of 4-chloro-5-(4-chlorophenyl)-3,6-dimethylpyridazine, and the mixture was stirred for 3 hours on an oil bath of 80° C. To the reaction mixture was added ethyl acetate, and the mixture was washed with brine four times. The organic layer was dried over anhydrous magnesium sulfate, then, concentrated under reduced pressure. 0.57 g of the resultant residue was subjected to silica gel column chromatography, to obtain 0.27 g of 5-(4-chlorophenyl)-4-(3-trifluoromethyl-1-pyrazolyl)-3,6-dim ethylpyridazine (hereinafter, described as compound (4) of the present invention.).

Provenance & Evidence