Hydrazine hydrate (1:1) → HCID 57743123, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.86 g of 4-(4-chlorophenyl)-3-(2,5-dimethyl-4-thiazolyl)-5-hydroxy-5-methyl-2(5H)-furanone, 0.18 g of hydrazine monohydrate and 8 ml of 1-butanol was heated under reflux for 5 hours. The reaction mixture was cooled to 0° C. The deposited solid was collected by filtration. The solid was washed with a mixed solvent of hexane and t-butyl methyl ether, and dried under reduced pressure to obtain 0.54 g of 5-(4-chlorophenyl)-4-(2,5-dimethyl-4-thiazolyl)-6-methyl-2H-pyridazin-3-one.

Provenance & Evidence