Chlorosuccinimide → HCID 42606319, compound

Participants

Reaction Steps

Example 9 (22 mg, 0.047 mmol) was dissolved in DMF (2 mL) and N-chlorosuccinimide (8 mg, 0.056 mmol) was added and the reaction was allowed to stir at r.t. for 4 hr. The mixture was concentrated in vacuo and purified by preparative HPLC (25/35 water/acetonitrile) to give 5 mg (21%) of the title compound. 1H NMR (400 MHz, MeOD): δ 7.98 (s, 1H), 7.50 (dd, 1H, J=10.0, 1.6 Hz), 7.44 (m, 1H), 6.87 (t, 1H, J=8.6 Hz), 4.17 (t, 2H, J=7.8 Hz), 3.59 (m, 2H), 3.34 (m, 2H), 3.17 (t, 2H, J=7.4 Hz), 2.43 (m, 2H). MS (ES) [m+H] calc'd for C17H16 ClFIN3O4, 508. found 508.

Provenance & Evidence