Bromine → 6-Bromothieno[2,3-d]pyrimidin-4(1H)-one

HRID 910200Notes

Reaction equation

HRID 910200 reaction equation
[N:1]1[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[C:4](=[O:10])[NH:3][CH:2]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[S:7][C:6]2[N:1]=[CH:2][NH:3][C:4](=[O:10])[C:5]=2[CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 2808547thieno(2,3-d)pyrimidin-4(3H)-one

Product 1

HCID 122173386-Bromothieno[2,3-d]pyrimidin-4(1H)-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A suspension of 3H-thieno[2,3-d]pyrimidin-4-one (7.68 g, 0.056 mol) in glacial acetic acid (75 ml) was treated with bromine (7.5 ml) and stirred at ambient temperature for 4 hours. The resulting solid was collected by filtration, washed with water and dried in vacuo to give 6-bromo-3H-thieno[2,3-d]pyrimidin-4-one as a light brown solid (11.64 g), which was used without further purification.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-a28f81e20c5c4d80bff95d375f4f9343
Source dataset
uspto-grants-2011_09
Patent number
US08022076B2

Reaction notes

Loading…