Acetic Acid → HCID 67382248, compound

HRID 910203Notes

Reaction equation

HRID 910203 reaction equation
[CH3:1][C:2]1[S:12][C:5]2[NH:6][C:7](=[O:11])[NH:8][C:9](=[O:10])[C:4]=2[CH:3]=1.C(O)(=O)C.[Br:17]Br>O>[Br:17][C:3]1[C:4]2[C:9](=[O:10])[NH:8][C:7](=[O:11])[NH:6][C:5]=2[S:12][C:2]=1[CH3:1]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24408BromineHCID 12724207HCID 12724207, compound

Product 1

HCID 67382248HCID 67382248, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A brown glass round-bottom flask was charged with 6-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione (2.70 g, 14.8 mmol) and glacial acetic acid (30 ml). Bromine (2.70 ml) was added and the mixture stirred at ambient temperature for 4 hours. The resultant mixture was diluted with water (30 ml) and the solid was collected by filtration, washed thoroughly with water and then dried in vacuo to give 5-bromo-6-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione as a brown solid (2.43 g), which was used without further purification.

Workup

  1. filtrationthe solid was collected by filtration
  2. washwashed thoroughly with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-cfa9fdeba9e34fe7ad6cdc06a7a0cf0c
Source dataset
uspto-grants-2011_09
Patent number
US08022076B2

Reaction notes

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