Sulfuric acid magnesium salt (1:1) → HCID 16738347, compound

Participants

Reaction Steps

4-(6-Iodoimidazo[1,2-a]pyridin-2-yl)benzonitrile (1.27 g) was added to a mixture of tetrahydrofuran (15 mL) and dichloromethane (15 mL), followed by stirring under ice cooling. Diisobutylaluminum hydride (7.8 mL) was added dropwise to the reaction mixture, and the resultant mixture was stirred at the same temperature for 15 minutes and then at room temperature for 4 hours. Aqueous saturated ammonium chloride solution (2 mL) was added dropwise to the reaction mixture, followed by stirring at room temperature for 1 hour. Subsequently, magnesium sulfate and diethyl ether were added to the reaction mixture, followed by further stirring for 1 hour. The solvent was evaporated, and the residue was purified through silica gel column chromatography (dichloromethane:methanol=95:5). The purified product was concentrated under reduced pressure, to thereby yield the title compound (1.03 g).

Provenance & Evidence