Chloroacetaldehyde → HCID 16735617, compound

Participants

Reaction Steps

4-(6-Iodoimidazo[1,2-a]pyridin-2-yl)-1-benzenecarbothioamide (249 mg) was dissolved in ethanol (10 mL). Triethylamine (91 μL) and chloroacetaldehyde (155 μL) were added to the solution, and the mixture was refluxed for 18 hours. Water was added to the reaction mixture, followed by extraction with dichloromethane-methanol. The solvent was evaporated, and the residue was purified through silica gel column chromatography (dichloromethane:methanol=100:5), followed by concentration under reduced pressure, to thereby yield the title compound (103 mg).

Provenance & Evidence