Dimethylformamide dimethyl acetal → HCID 16735150, compound

Participants

Reaction Conditions

Reaction Steps

N,N-dimethylformamide dimethyl acetal (363 μL) was added dropwise to a solution (50 mL) of 1-[4-(6-iodoimidazo[1,2-a]pyridin-2-yl)phenyl]-1-ethanone (495 mg) in dimethylformamide, and the mixture was heated at 150° C. for 16 hours. The reaction mixture was concentrated, and the residue was purified through silica gel column chromatography (dichloromethane:methanol=97:3), followed by concentration under reduced pressure, to thereby yield the title compound (274 mg).

Provenance & Evidence