HCID 67403343, compound → HCID 178505450, compound

HRID 910240Notes

Reaction equation

HRID 910240 reaction equation
FC1C=CC2[N:6](C=C(C3C=CC(C(=O)C)=CC=3)N=2)C=1.C[N:21](C)/[CH:22]=[CH:23]/[C:24]([C:26]1[CH:31]=[CH:30][C:29]([C:32]2[N:33]=[C:34]3[CH:39]=[CH:38][C:37]([F:40])=[CH:36][N:35]3[CH:41]=2)=[CH:28][CH:27]=1)=O>>[F:40][C:37]1[CH:38]=[CH:39][C:34]2[N:35]([CH:41]=[C:32]([C:29]3[CH:30]=[CH:31][C:26]([C:24]4[CH:23]=[CH:22][NH:21][N:6]=4)=[CH:27][CH:28]=3)[N:33]=2)[CH:36]=1

Participants

3

Reactant 2

HCID 67403343HCID 67403343, compoundHCID 67405778HCID 67405778, compound

Product 1

HCID 178505450HCID 178505450, compoundYield 69.5%

Procedure

The procedure of Referential Example 6 was repeated, except that 1-[4-(6 fluoroimidazo[1,2-a]pyridin-2-yl)phenyl]-1-ethanone (410 mg), which had been produced in Referential Example 28 was used, to thereby yield (E)-3-(dimethylamino)-1-[4-(6-fluoroimidazo[1,2-a]pyridin-2-yl)phenyl]-2-propen-1-one (120 mg). Subsequently, The procedure of Referential Example 3 was repeated, to thereby yield the title compound (75 mg).

Workup

  1. customhad been produced in Referential Example 28

Sources & evidence

ORD record
ord-dc02bf4d959f4d14877fbcdff952d765
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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