Sodium Hydroxide → HCID 178506535, compound

Participants

Reaction Conditions

Reaction Steps

Subsequently, tert-butyl 3-[4-(6-iodo-1,3-benzoxazol-2-yl)phenyl]-1H-1-pyrazolecarboxylate (49 mg) was dissolved in a mixture of tetrahydrofuran (2 mL) and ethanol (2 mL), and 6N hydrochloric acid (500 μL) was added to the solution, followed by stirring at 80° C. for 2 hours. The reaction mixture was alkalified with 1N sodium hydroxide, followed by stirring at 80° C. for 1 hour. The reaction mixture was concentrated under reduced pressure, followed by drying. The thus-obtained white solid was recovered through filtration, and washed sequentially with water and ethanol, followed by drying under reduced pressure, to thereby yield the title compound (26 mg).

Provenance & Evidence