Dimethylformamide dimethyl acetal → HCID 178483563, compound

Participants

Reaction Conditions

Reaction Steps

Subsequently, 1-[4-(5-bromo-1H-benz[d]imidazol-2-yl)phenyl]-1-ethanone (592 mg) and N,N-dimethylformamide dimethyl acetal (468 μL) were dissolved in N,N-dimethylformamide (10 mL), followed by heating at 100° C. for 2 hours. The reaction mixture was concentrated, and the residue was subjected to flash chromatography. Fraction eluted by dichloromethane-methanol (15:1) were concentrated under reduced pressure, followed by recovering the solid through filtration by use of isopropyl ether, to thereby yield a 1:1 mixture (116 mg) of (E)-1-[4-(5-bromo-1H-benz[d]imidazol-2-yl)phenyl]-3-dimethylamino-2-propen-1-one and (E)-1-[4-(6-bromo-1H-benz[d]imidazol-2-yl)phenyl]-3-dimethylamino-2-propen-1-one.

Provenance & Evidence