(4-methyl-4H-1,2,4-triazol-3-yl)methanamine → 5-Butyl-1-(5-methyl-4-(thiazol-5-yl)pyrimidin-2-yl)-N-((4-methyl-4H-1,2,4-triazol-3-yl)methyl)-1H-pyrazole-4-carboxamide

Participants

Reaction Steps

Compound 27 was prepared from 5-butyl-1-(5-methyl-4-(thiazol-5-yl)pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid following procedures described in Example 1 with the exceptions of substituting thiophene-2-boronic acid with thiazole-5-boronic acid in Step 1 and substituting pyridine-4-ylmethylamine with (4-methyl-4H-1,2,4-triazol-3-yl)methanamine. 1H NMR (400 MHz, MeOD-d3) δ 0.85 (t, J=7.3 Hz, 3H), 1.36 (m, 2H), 1.61 (m, 2H), 2.69 (s, 3H), 3.56 (t, J=7.4 Hz, 2H), 3.97 (s, 3H), 4.81 (s, 2H), 7.63 (s, 1H), 8.15 (s, 1H), 8.61 (s, 1H), 8.81 (s, 1H), 8.98 (s, 1H), 9.17 (s, 1H). LCMS (ES+) m/z 438 (M+1).

Provenance & Evidence