HCID 57916409, compound → HCID 60207864, compound

Participants

Reaction Steps

The title compound 99 was prepared by following the synthetic sequence and conditions described in Example 14 and Example 16 with the following modifications. First in Step 2 of Example 14, intermediate D.2 (R2=methyl, R3=H) was treated with (Z)-methyl 2-((dimethylamino)methylene)-4-ethoxy-3-oxobutanoate, instead of (Z)-methyl 2-((dimethylamino)methylene)-3-oxoheptanoate, to give D.3 (R2=methyl, R4=ethoxymethyl). This intermediate D.3 was converted to the corresponding D.5, 1-(4-chloro-5-methylpyrimidin-2-yl)-5-(ethoxymethyl)-N-((1-methyl-1H-imidazol-5-yl)methyl)-1H-pyrazole-4-carboxamide, in three steps (Steps 3-5).

Provenance & Evidence