Ammonium formate → HCID 59312404, compound

Participants

Reaction Steps

To a stirred solution of ((3RS,4SR)-1-Benzyl-4-phenyl-pyrrolidin-3-yl)-methyl-carbamic acid tert-butyl ester (2.03 g, 5.56 mmol) in MeOH (20 ml) at RT, was added ammonium formate (1.60 g, 25.4 mmol) and palladium on charcoal (0.40 g, 10%) The reaction mixture was stirred for 2 hours, filtrate on celite and concentrated under vacuo. The residue was purified by column chromatography (CH2Cl2/MeOH, 9/1) to give 0.57 g (41%) of the title product as a waxy solid.

Provenance & Evidence