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HRID910605

反应详情

EQUATION

反应方程式

HRID 910605 的结构方程式

REACTANTS

反应物

2
结构：C[C@]12CC[C@H]3[C@@H](C(=O)C=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O
HCID11426682

未命名化合物

结构：C[C@]12CCCCC1CC(=O)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID68950713

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@H]3[C@@H](C(=O)CC4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O
HCID66910149

未命名化合物

收率 95.1%

PROCEDURE

实验过程

3β,17β-Dihydroxyandrostan-7-one was prepared in 96% yield from 3β,17β-dihydroxyandrost-5-en-7-one (700 mg) by the procedure described above for the preparation of 3,3:17,17-bis(ethylendioxy)androstane-7-one (Prepn. 9). The crude product was purified by flash chromatography (SiO2, hexane/acetone/CH2Cl2 10/10/10) to give 3β,17β-dihydroxyandrostane-7-one (670 mg). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 4.53 (bb, 1H), 4.44 (bb, 1H), 3.47-3.27 (m, 2H), 2.45-2.31 (m, 2H), 2.05-1.91 (m, 1H), 1.89-0.78 (m, 17H), 0.99 (s, 3H), 0.59 (s, 3H).

WORKUP

后处理

  1. customdescribed above for the preparation of 3,3
  2. customThe crude product was purified by flash chromatography (SiO2, hexane/acetone/CH2Cl2 10/10/10)