HCID 66910124, compound → HCID 66910127, compound

Participants

Reaction Steps

6-Azaandrostane-3,7,17-trione was prepared from 3β-hydroxy-6-azaandrostane-7,17-dione by the procedure described above for the preparation of 3β,17β-di(dimethyltert-butylsilyloxy)androstane-6-one and 3α,17β-di(dimethyltert-butylsilyloxy)androstane-6-one (Prepn. 12). The mixture was stirred for 35 minutes, then SiO2 was added and evaporated to dryness. The mixture was purified by flash chromatography (SiO2, acetone/toluene 1/1) to give 6-azaandrostane-3,7,17-trione (75%). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 7.34 (s, 1H), 3.31 (dd, 1H), 2.57-1.07 (m, 17H), 0.99 (s, 3H), 0.83 (s, 3H).

Provenance & Evidence