2-Bromo-1-(4-hydroxyphenyl)ethanone → HCID 24864011, compound

Participants

Reaction Conditions

Reaction Steps

748 mg (corresponding to 3.48 mmol) of 2-bromo-4′-hydroxyacetophenone and 605 mg (corresponding to 3.48 mmol) of 5-bromo-2-aminopyrimidine were dissolved in 30 mL of acetonitrile. The resulting solution was refluxed in an oil bath at 110° C. for 5 hours. After the completion of the reaction, the reaction solution was cooled down to room temperature, and precipitates were filtered and recovered. The precipitates were washed with acetonitrile and dried under reduced pressure. The resulting crude crystals were suspended in a mixed solution of 10 mL of water and 15 mL of methanol. Then, about 10 mL of a saturated sodium hydrogencarbonate solution was added thereto, and the mixture was sonicated for 5 minutes using an ultrasonic washing machine. Precipitates were filtered and recovered from the resulting mixture, sufficiently washed with water, and dried under reduced pressure. The obtained solid was recrystallized from N,N-dimethylformamide, to obtain 289 mg (corresponding to 1.00 mmol) of 6-bromo-2-(4′-hydroxyphenyl)imidazo[1,2-a]pyrimidine (FIG. 10, Step 2).

Provenance & Evidence