HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Piperidin-1-yl)acetic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Piperidineacetic acid, ethyl ester | HCID 643466 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(Piperidin-1-yl)acetic acid hydrochloride | HCID 201096 | 83% |
Reaction Steps
Ethyl 2-(piperidin-1-yl)-acetate (5.5 g, 32.2 mmol), water (12 ml) and c HCl (3 ml) were heated under reflux for 20 hours. Volatile components were evaporated under reduced pressure to leave an off white solid. This solid was co-evaporated with toluene (50 ml×3) and dried in vacuo to give an off white powder (Yield 4.8 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022211B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-2f23f5faca1145ea821153e984272306 |
| Source note | uspto-grants-2011_09 |