4-Ethoxycarbonylphenylboronic acid → 4-[1-(2,5-Difluorobenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]benzoic acid ethyl ester

HRID 91068Notes

Reaction equation

HRID 91068 reaction equation
[CH2:22]([CH3:23])[O:24][C:25](=[O:26])[c:27]1[cH:28][cH:29][c:30]([B:33]([OH:34])[OH:35])[cH:31][cH:32]1.[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:12][cH:13][c:14]([I:16])[cH:15]3)[NH:8][CH2:9][C:10]2=[O:11])[cH:17][c:18]([F:21])[cH:19][cH:20]1>>[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:12][cH:13][c:14](-[c:30]4[cH:29][cH:28][c:27]([C:25]([O:24][CH2:22][CH3:23])=[O:26])[cH:32][cH:31]4)[cH:15]3)[NH:8][CH2:9][C:10]2=[O:11])[cH:17][c:18]([F:21])[cH:19][cH:20]1

Participants

3

Reactant 2

HCID 27343504-Ethoxycarbonylphenylboronic acidHCID 670918851-(2,5-Difluorobenzyl)-7-iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one

Product 1

HCID 248530164-[1-(2,5-Difluorobenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]benzoic acid ethyl ester

Sources & evidence

ORD record
ord-99b1274a26934897aa1c338efdb888f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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