Nitrogen → HCID 25216554, compound

Participants

Reaction Conditions

Reaction Steps

To a N2 flushed vial was sequentially added trifluoromethanesulfonic acid 3-[4-(4-methyl-piperazin-1-yl)-pyridin-2-yl]-phenyl ester (20 mg, 0.05 mmol), Pd(PPh3)4 (10 mg), and toluene/EtOH (4:1, 1 mL). After 5 min, 4-fluorophenylboronic acid (10 mg, 0.07 mmol) and 2 M aqueous K2CO3 (0.2 mL) were added. The resulting mixture was heated at 90° C. for 16 h, then was poured into water and extracted with CH2Cl2. The organic layer was dried and concentrated, and the resulting residue was purified by preparative TLC (MeOH/CH2Cl2) to yield the title compound as a solid.

Provenance & Evidence