HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine | HCID 1714225 | — |
Reaction Steps
To a solution of 2,4-dichloropyrimidine (740 mg, 5 mmol) in EtOH (15 mL) was slowly added 1-methylpiperazine (550 mg, 5.5 mmol). The resulting mixture was stirred at room temperature overnight, then was concentrated, diluted with water, and extracted with CH2Cl2. The organic layer was dried and concentrated to yield 2-chloro-4-(4-methyl-piperazin-1-yl)-pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022209B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-73e60837939b41ff82c9ae5a0b6276c6 |
| Source note | uspto-grants-2011_09 |