1,2-Dichloroethane → HCID 25216688, compound

Participants

Reaction Steps

To a solution of 3′-[4-(4-methyl-piperazin-1-yl)-pyridin-2-yl]-biphenyl-4-carboxylic acid (30 mg, 0.08 mmol) in DMF (2 mL) was added morpholine (16 mg, 0.16 mmol), EDC (20 mg, 0.1 mmol), and Et3N (10 mg, 0.1 mmol). The resulting mixture was stirred at room temperature overnight, and then was poured into water and extracted with CH2Cl2. The organic layer was washed with 1 N HCl, 2 M aqueous Na2CO3, dried, and concentrated, and the resulting residue was purified by preparative TLC (MeOH/CH2Cl2) to yield the title compound as a white solid.

Provenance & Evidence