Potassium Carbonate → 4-(4-Methyl-piperazin-1-yl)-2-phenyl-pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	Phenylboronic Acid	HCID 66827	—
Reactant	2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine	HCID 1714225	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	Toluene ethanol	HCID 21863594	—
Product	4-(4-Methyl-piperazin-1-yl)-2-phenyl-pyrimidine	HCID 57613194	—

Reaction Conditions

Temperature	140 °C

Reaction Steps

To a microwave tube was added 2-chloro-4-(4-methyl-piperazin-1-yl)-pyrimidine (30 mg, 0.14 mmol), Pd(PPh3)4 (10 mg), phenylboronic acid (24 mg, 0.2 mmol), toluene/EtOH (4:1, 1 mL) and 2 M aqueous K2CO3 (0.2 mL). The resulting mixture was heated at 140° C. for 30 minutes using the microwave instrument. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08022209B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-8146377012cc4b809b7a9acba3452ec6
Source note	uspto-grants-2011_09