Cesium fluoride → HCID 57613225, compound

Participants

Role	Name	HCID	Charge
Reactant	Cesium fluoride	HCID 25953	—
Reactant	2-(Di-tert-butylphosphino)biphenyl	HCID 2734215	—
Reactant	2-(Tri-n-butylstannyl)thiophene	HCID 2779373	—
Reactant	2-Chloro-6-(4-methylpiperazino)pyridine	HCID 10727230	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 57613225	HCID 57613225	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

To a vial was added 1-(6-chloro-pyridin-2-yl)-4-methyl-piperazine (27 mg, 0.13 mmol), Pd2(dba)3 (14 mg), 2-(di-t-butylphosphino)biphenyl (18 mg), 2-thienyltributylstannane (51 mg, 0.15 mmol), dioxane (1 mL) and CsF (39 mg, 0.26 mmol). The resulting mixture was heated at 100° C. for 24 hrs. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08022209B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-e84f367a4c514c37bf6b86f5ba7227bb
Source note	uspto-grants-2011_09