HCID 57613244, compound → HCID 57613221, compound

HRID 910701Notes

Reaction equation

HRID 910701 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([C:14]3[CH:18]=[C:17]([CH:19]=[CH2:20])[S:16][CH:15]=3)[CH:9]=2)[CH2:4][CH2:3]1>C(O)C.[Pd]>[CH2:19]([C:17]1[S:16][CH:15]=[C:14]([C:10]2[CH:9]=[C:8]([N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)[CH:13]=[CH:12][N:11]=2)[CH:18]=1)[CH3:20]

Participants

4

Reactant 1

HCID 57613244HCID 57613244, compound

Product 1

HCID 57613221HCID 57613221, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1-Methyl-4-[2-(5-vinyl-thiophen-3-yl)-pyridin-4-yl]-piperazine in ethanol was treated with a catalytic amount of 10% palladium on carbon and placed under an H2 atmosphere at room temperature. The resulting mixture was filtered and concentrated to yield the title compound.

Workup

  1. customplaced under an H2 atmosphere at room temperature
  2. filtrationThe resulting mixture was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-256becd39a964b70a5c0c54f4196f610
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

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