HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-5-ethoxy-4-hydroxybenzaldehyde → 4-(2-Amino-pyridin-3-ylmethoxy)-3-bromo-5-ethoxy-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-5-ethoxy-4-hydroxybenzaldehyde | HCID 612496 | — |
| Reactant | (2-Aminopyridin-3-yl)methanol | HCID 11159325 | — |
| Product | 4-(2-Amino-pyridin-3-ylmethoxy)-3-bromo-5-ethoxy-benzaldehyde | HCID 86624411 | — |
Reaction Steps
Mitsunobu reaction of 3-bromo-5-ethoxy-4-hydroxy benzaldehyde (490 mg) with (2-amino-pyridin-3-yl)-methanol (250 mg) was preformed according to the method described for example 21d. The residue was chromatographed on silica gel in dichloromethane/methanol=99/1 (v/v) as eluent. Yield: 500 mg. MS-ESI: [M+H]+=351/353.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022218B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-cc0a08cc8b2b433fadb01ceb96f0e026 |
| Source note | uspto-grants-2011_09 |