Ammonium Acetate → (s)-3-Amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide

Participants

Reaction Conditions

Reaction Steps

To a suspension of (S)—N-[1-(4-methoxy-phenyl)-ethyl]-3-oxo-butyramide (10 g) in toluene (800 ml) was added at 20° C. ammonium acetate (10 g) and the reaction was heated for 20 h at 100° C. in a Dean Stark system. The mixture was concentrated in vacuo and the product obtained was used without further purification in the following reaction step.

Provenance & Evidence