反应详情

温度

80 °C

A mixture of (S)-3-amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide (10 g), 3-bromo-5-ethoxy-4-hydroxy-benzaldehyde (10.4 g) and 5-propylcyclohexane-1,3-dione (6.5 g) in ethanol (150 ml) was stirred at 80° C. for 18 hr. The mixture was concentrated in vacuo. The residue was dissolved in toluene (100 ml) and dichloromethane (50 ml) and evaporated until a precipitated formed. The solid obtained was then crystallized in EtOAc.

1. concentrationThe mixture was concentrated in vacuo
2. dissolutionThe residue was dissolved in toluene (100 ml)
3. customdichloromethane (50 ml) and evaporated until a precipitated
4. customformed
5. customThe solid obtained
6. customwas then crystallized in EtOAc