Sodium Hydroxide → HCID 178449980, compound

Participants

Reaction Steps

An aqueous solution (8.5 ml) of sodium hydroxide (1 mol/liter) was added, at room temperature, to a mixed solution in methanol (9.5 ml) and dioxane (19 ml) of the 2-(2-{[(4-chlorophenyl)sulfonyl]amino}pentanoyl)-N-methylhydrazine carbothioamide (2.157 g) obtained in Example 1-(3). The mixture was stirred for 30 minutes, and then stirred for 30 minutes at 85° C. The solvent was distilled off from the reaction mixture, and an aqueous solution (20 ml) of hydrochloric acid (0.5 mol/liter) was added to the residue. The mixture was extracted with ethyl acetate (100 ml), and washed with a saturated aqueous solution (100 ml) of sodium chloride.

Provenance & Evidence