Methylamine → HCID 67061830, compound

Participants

Reaction Steps

According to general procedure D, 1.0 mmol of 3-[(2S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-2,2-dimethyl-propionic acid are reacted with methylamine (8M in EtOH) to afford the title compound as yellow oil. Rf=0.25 (EtOAc/heptane 3:1); Rt=5.36 (gradient I).

Provenance & Evidence