Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Cyanophenol | HCID 13394 | — |
| Reactant | 2-Fluoro-4-(trifluoromethyl)benzaldehyde | HCID 522929 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86620099 | HCID 86620099 | — |
Reaction Steps
A mixture of 4-(1,1,1-trifluoromethyl)-2-fluoro-benzaldehyde (2.5 g), potassium carbonate (1.79 g) and 3-cyanophenol (1.54 g) in DMF (20 ml) was heated at 110° C. for 2 h then cooled. Water (200 ml) was added and the mixture extracted with ethyl acetate, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/diethylether 2:1 to give a colourless oil, yield 2.0 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08022248B2 |
|---|
| Source dataset | uspto-grants-2011_09 |
|---|
| ORD ID | ord-dbe6dd58add148f3abf6b8dc4e991f8b |
|---|
| Source note | uspto-grants-2011_09 |
|---|
