Sodium Chloride → HCID 11667157, compound

Participants

Reaction Conditions

Reaction Steps

Sodium chloride (0.1 g) was added to a solution of the product from step (iv) (0.6 g) in DMSO (5 ml) and water (1 ml) then heated at 120° C. for 12 hours. The mixture was cooled and partitioned between 2M sodium hydroxide and diethylether. The aqueous layer was acidified with 2M hydrochloric acid, extracted with ethyl acetate and the organic layer dried and evaporated under reduced pressure. The residue was purified by reverse phase HPLC. Yield 0.108 g.

Provenance & Evidence