反应详情

A solution of sodium methoxide (25% wt in methanol, 50 ml) was added to a solution of (4-(1,1,1-trifluoromethyl)-2-fluoro-benzaldehyde (5.0 g) in methanol (50 ml) and the mixture heated under reflux for 2 h. Water (200 ml) was added and the mixture extracted with ethyl acetate. The organics were dried and evaporated under reduced pressure to give a residue that was purified by chromatography on silica eluting with isohexane/diethylether 3:1, yield 3.18 g.

1. temperaturethe mixture heated
2. temperatureunder reflux for 2 h
3. extractionthe mixture extracted with ethyl acetate
4. customThe organics were dried
5. customevaporated under reduced pressure
6. customto give a residue that
7. customwas purified by chromatography on silica eluting with isohexane/diethylether 3:1, yield 3.18 g