Lithium Chloride → 2-Hydroxy-4-(trifluoromethyl)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

A mixture of the product from step (i) (3.18 g) and lithium chloride (1.96 g) in DMF (30 ml) was heated at 150° C. for 5 h. The mixture was partitioned between diethylether and 2M hydrochloric acid, the organic layer dried, and the solvent evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/diethylether 3:1, yield 2.30 g.

Provenance & Evidence