tert-Butyl (2E)-3-[2-(benzyloxy)-4-(trifluoromethyl)phenyl]acrylate → tert-Butyl 3-[2-hydroxy-4-(trifluoromethyl)phenyl]propanoate

Participants

Reaction Steps

A mixture of the product from step (iv) (3.25 g) and 10% palladium on carbon (0.325 g) in ethanol (40 ml) was hydrogenated at a pressure of 3.0 bar overnight. The mixture was filtered through celite and the filtrate concentrated under reduced pressure to give a white solid (2.22 g).

Provenance & Evidence