Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Butyn-1-ol | HCID 12991 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | 2-Chloro-4-(ethylsulfonyl)-1-fluorobenzene | HCID 57904725 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 67391845 | HCID 67391845 | — |
Reaction Steps
The product from example 4 step (i) (1.0 g) in dry NMP (20 ml) was treated with 2-butyn-1-ol (0.63 ml) and sodium tert-butoxide (0.864 g) and the mixture stirred at 80° C. for 2 h. The mixture was partitioned between water/ethyl acetate, the organics separated, dried and evaporated under reduced pressure, yield 1.06 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08022248B2 |
|---|
| Source dataset | uspto-grants-2011_09 |
|---|
| ORD ID | ord-c490410b12a6440d80edc89b7c469e88 |
|---|
| Source note | uspto-grants-2011_09 |
|---|
