Ethyl bromoacetate → HCID 67390618, compound

Participants

Reaction Steps

A mixture of the product from step (iii) (0.95 g), ethyl bromoacetate (0.145 ml) and sodium acetate (0.160 g) in dry ethanol (30 ml) was heated under reflux 24 h. A further 5 equivalents of ethyl bromoacetate were added and heated for a further 48 h. The mixture was partitioned between water/ethyl acetate, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/diethylether 1:1, yield 0.44 g.

Provenance & Evidence