2-(Tributylstannyl)pyridine → N-[4-chloro-2-[2-chloro-4-(2-pyridinyl)phenoxy]phenyl]-glycine, ethyl ester

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Reaction Steps

The subtitle compound was prepared by using the product from example 30 step ii) (0.20 g) which was dissolved in dry dioxane (10 ml). 2-pyridyl tributyl tin (0.181 g) and palladium (0) tetrakistriphenylphosphine (0.028 g) were added and the mixture was heated at 80 C for 16 hours. The mixture was diluted with water, extracted with ethyl acetate, dried and concentrated under reduced pressure to give an oil. Yield 0.20 g.

Provenance & Evidence