Potassium Carbonate → HCID 67390461, compound

Participants

Reaction Steps

A mixture of 2-amino-5-chlorophenol (11.0 g), 2-chloro-1-fluoro-4-nitrobenzene (1.5 g) and potassium carbonate (2.8 g) in dry DMF (20 ml) was stirred room temperature for 1 h then heated at 60° C. for 2 h. The mixture was partitioned between water/ethyl acetate, the organics separated, washed with water, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 10% ethylacetate/isohexane, yield 1.96 g.

Provenance & Evidence