Ethyl bromoacetate → HCID 67391626, compound

Participants

Reaction Steps

A mixture of the product from step (i) (0.3 g), ethyl bromoacetate (0.22 ml) and sodium acetate (0.164 g) in dry ethanol (5 ml) was heated under reflux 7 h. Ethyl bromoacetate (0.5 ml) and sodium acetate (0.34 g) were added and heated for a further 16 h. The solvent was evaporated under reduced pressure and the residue purified by chromatography on silica eluting with 5-7% ethylacetate/isohexane, yield 0.212 g.

Provenance & Evidence